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People with progressive MS have elevated TNF- expression in the cortex and meninges which shifts the TNF receptor expression balance from a TNFR2 cell survival to TNFR1 cell death [193, 231]
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HSCs ROS play a critical role in the differentiation and activation of HSCs into myofibroblasts, which in turn leads to the secretion and accumulation of collagen and other ECM components in the liver [131]
Ying W, Wei G, Wang D, et al
Research has confirmed that inhibiting polyamine biosynthesis with the ornithine decarboxylase inhibitor -difluoromethylornithine significantly mitigates increased BBB permeability, Evans blue extravasation, and brain tissue water content in models of cerebral ischemia (102)
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