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Interestingly, peripheral inflammation induced by TLR-4 activation by systemic LPS exacerbated kainic-acid induced seizures and elevated hippocampal reactive microglia, levels of IL-1, TNF, and IL-6, and NOX subunit expression ( Tumor necrosis factor alpha (TNF) further impacts the oxidative environment and metabolism in the brain by targeting mitochondria

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PC showed no cytotoxicity on BMDMs up to 100 M (Fig

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 90% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

Pregnancy/breastfeeding: Unknowndefer

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