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Importantly, NF-B signal activation, as a downstream promoter element of TNF-, is negatively suppressed in intracellular survival signaling (57) ( Figure 5 )

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323,328,329 Interestingly, a dual genetic lineage tracing approach revealed the mechanism underlying the origin of LPCs

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4), consistent with its significantly elevated mRNA expression and reduced expression of E-cadherin (Fig

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