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But that caloric deficit creates a metabolic challenge: rapid mobilisation of adipose tissue releases free fatty acids into circulation faster than the liver can process them without sufficient lipotropic cofactors

Mileykovskiy, B

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

The head is the hydrophilic part, and the tail contains the hydrophobic fatty acids

Moreover, insulin content and glucose-induced insulin secretion in INS1E cells overexpressing wild type PKC were similar to control, which shows that increased level of PKC did not impair -cell function [126]