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Acknowledgments This study was approved by the ethics committee of Shengjing Hospital of China Medical University (No.2016PS43K) and the Animal Ethics Committee of China Medical University

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Additionally, the combined treatment facilitates apoptosis execution by inhibiting members of the BIRC family, proteins renowned for impeding programmed cell death

Several cases of scurvy in children due to KD use have been reported in the literature (64, 244)

The ischemic phase induces cellular metabolic disturbance due to glycogen consumption, ATP depletion, and lack of oxygen supply, whereas the reperfusion phase results in metabolic disturbance and an unusual immune-inflammatory response that involves both direct and indirect cytotoxic mechanisms (Zhai et al., 2013)

doi: 10.1016/j.brainres.2009.06.038