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333,334 However, in patients with T2DM, correcting hyperglycemia with insulin therapy has a limited impact on DPN

Environ Sci Technol 34:20572063 [Google Scholar] Dargel R (1992) Lipid peroxidation-a common pathogenetic mechanism

Par et al

Therapeutic strategies targeting the SSP have emerged as a research hotspot, encompassing dietary intervention, the development of inhibitors targeting key enzymes such as phosphoglycerate dehydrogenase (PHGDH), as well as combination therapies with radiotherapy, chemotherapy and immunotherapy

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Patients often report fatigue, cold intolerance, and reduced physical activity, further compounding weight-related challenges