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A study in mice with PCOS found that semaglutide alleviated autophagy and ovarian oxidative stress via the PI3K/AKT/mTOR (phosphatidylinositol 3 kinase/protein kinase B/mammalian target of rapamycin) pathway [42] , further establishing a theoretical framework for the clinical application of GLP-1 RAs in PCOS

Effects on Brain Development: Since GLP-1 receptors are expressed in the brain, there is interest in understanding their long-term impact on cognitive function and appetite regulation

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The Newcastle-Ottawa Scale was used for the quality assessment of the included cohort studies

Marks points out that at that time the two hormones produced by pancreatic islet A and B cells were regarded as 'biological antagonists rather than subtle collaborators in blood glucose control' (Marks 2018)

25 In the early 1990s, despite John Engs team identifying a potential diabetes treatment in exendin-4, it initially lacked attention and funding for development