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The most common issues are cosmetic and mild: transient stinging or redness, dryness, and occasionally a faint bluish or brownish tint on the skin from the copper, particularly at higher concentrations

Currently, there is a phase 1 clinical trial to evaluate daratumumab in decreasing circulating antibodies in sensitized recipients awaiting heart transplantation (ClinicalTrials.gov, NCT04088903)

The adult rat is the species of choice due to its well-documented physiological responses, established baseline toxicology data, and extensive use in regulatory testing frameworks

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It can be legally purchased for research purposes in many regions
