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Treatment with a small-molecule ferroptosis inhibitor ameliorated neurodegeneration in those mice (Hambright et al., 2017), and induced the upregulation of GPX4 expression and inhibition of neuronal ferroptosis by reducing albumin extravasation and BBB injury (Peng et al., 2021)
This review summarizes the role and regulation of the HIF-1 in cancer and recent therapeutic approaches targeting this important pathway
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mTOR activation promotes glycolysis
