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Brain 132 , 23362349 (2009)

ROS functions as a mediator for the signaling switch between metabolism and stem cell fate by decreasing the capacity of HSCs to repopulate [52,53]

In aged mammalian models, administering FOXO4-DRI decreases the accumulation of senescent cells, restores cerebral blood flow and the integrity of the bloodbrain barrier (BBB), reverses hippocampal atrophy, and enhances cognitive function

[6] This role in energy production may contribute to its therapeutic effects in metabolic conditions

Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation