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To understand the system, the behavior of each part is studied individually, without considering the interactions among the set of parts [42]
doi: 10.1007/s40265-021-01611-0 156 HoferU
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Am J Physiol Lung Cell Mol Physiol 291: L811L819
Unlike disorders driven primarily by protein aggregation at the organelle level, HD is fundamentally a disease of profound systemic metabolic reprogramming initiated by early nuclear transcriptional dysregulation
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