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Although the exact etiology of IPF remains unclear, emerging evidence suggests that ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation and oxidative stress, plays a significant role in its pathogenesis

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2) Due to the extremely complex signaling pathways in the regulation of normal cellular biology, inhibition of a specific signaling pathway will definitely have feedback activation or upregulation of other alternative signaling pathways, therefore causing ultimately treatment failure
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