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Excessive vitamin B12 supplementation can cause anxiety, jitters, rapid heart rate, heart palpitation, and fatigue

The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases

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The combination of these methods represents a paradigm shift of phytochemical oncology to enhance pharmacokinetics, targeting, and therapeutic response to clinical applicability ( Table 2 )

Cacciatore et al., 2010