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The 5,10-methylene dehydrogenase activity of the MTHFD1 encoded enzyme converts 5,10-methylene-THF to 5,10-methenyl-THF
When patients with cystic fibrosis were given glycine (0.5 g/kg/day in fluid) for 8 weeks in a double-blind crossover protocol, FEV 1 increased significantly and symptom score improved significantly during supplemental glycine

A.Sempere-FerreF.SantamarinaC.RosellJ.SantamarinaM

All studies adhered to procedures consistent with the National Research Council Guide for the Care and Use of Laboratory Animals, and were approved by the Institutional Animal Care and Use Committee of the Inner Mongolia University
