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Our heartfelt thanks go out to our colleagues and peers across the globe whose invaluable contributions, insights, and expertise have significantly enriched this manuscript

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The 5,10-methylene dehydrogenase activity of the MTHFD1 encoded enzyme converts 5,10-methylene-THF to 5,10-methenyl-THF

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When patients with cystic fibrosis were given glycine (0.5 g/kg/day in fluid) for 8 weeks in a double-blind crossover protocol, FEV 1 increased significantly and symptom score improved significantly during supplemental glycine

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A.Sempere-FerreF.SantamarinaC.RosellJ.SantamarinaM

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All studies adhered to procedures consistent with the National Research Council Guide for the Care and Use of Laboratory Animals, and were approved by the Institutional Animal Care and Use Committee of the Inner Mongolia University

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