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Moreover, while the use of ASNS alone can cause adverse effects such as pancreatitis and thrombosis, its combination with CB-839 effectively mitigates these risks ( 4.3.5 Combination of ammonium metabolism drugs and radiotherapy Excessive ROS production leads to an imbalance between ROS and the cells antioxidant defense, resulting in DNA damage, a key mechanism in radiation therapy-mediated tumor treatment (40)

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Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura

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Peripheral blood monocytes of such patients demonstrate altered bioenergetics and reduced basal respiration, reduced spare respiratory capacity, and decreased proton leak 172

While the body produces glutathione naturally, there are several factors, such as environmental stressors and aging, that can deplete its levels