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Some people reject therapies studied in large populations while accepting compounds with little or no human data

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Most published research describes Pinealon as well tolerated

Dimethyl fumarate (DMF), as an Nrf2 activator, can activate the Nrf2-TIGAR-LAMP2/Catepsin D pathway to regulate autophagy and cell apoptosis, thereby improving rotenone induced DAergic neurodegeneration [52]