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Metformin use and risk of B12 deficiency increases with the dose and the duration depletion can be seen as early as 3-4 months after starting so it is important to attend for follow up blood tests and talk to your doctor

doi: 10.1001/jama.2012.113905

Whether its due to diet, stress, age, or absorption issues, a deficiency can cause fatigue, brain fog, irritability, and more

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Therefore, the only source of this vitamin in the diet is animal products [3]
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