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Finally, to provide further proof that HuR controls KGA levels, we used the CRISPR-Cas9 knock-in system to modify the GLS gene by introducing a fluorescence protein (mKO2 49 ) within exon 19 to express KGA fused to mKO2 at its C-terminus (Fig

Lowering low-density lipoprotein cholesterol (LDL-c) can reduce the risk of atherosclerotic cardiovascular disease in patients without a diagnosis of CVD (primary prevention) or decrease the risk of recurrent disease (secondary prevention)