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It is not a magic bullet and it will not do away with surgery or fix structural issues such as bone-on-bone arthritis, or reverse severe deformities

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They are not for human or veterinary use and are not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease

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Neelakantan H, Vance V, Wetzel MD, Wang HY, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochem Pharmacol. 2018 Jul;154:161-171. doi: 10.1016/j.bcp.2018.05.003. Epub 2018 May 5. PMID: 29738706; PMCID: PMC6015571
