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doi:10.1093/jn/136.1.75

Bailey, J

When injected subcutaneously, the peptide reaches peak plasma levels within 1-3 hours and is cleared relatively rapidly, likely through peptidase degradation and renal filtration

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Although bitopertins selectivity for GlyT1 may not have provided sufficient synaptic glycine elevation in relevant cortical areas or may have induced compensatory mechanisms that attenuated its efficacy, iclepertin (BI 425809), which was developed following the bitopertin setback, showed promise in early trials and even reached phase III (Reuteman-Fowler et al

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