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GLP-1 agonists such as semaglutide act through GLP-1 receptors, whereas cagrilintide acts through amylin/calcitonin receptors in the hindbrain area postrema, sending a vagal signal that decelerates the stomach

Patients may notice reduced pallor and improved exercise tolerance as anaemia resolves

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This suggests that chronic disruption of the TCA cycle, as opposed to acute inhibition, may be an adaptive response to metabolic changes

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