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MC38 tumorbearing mice were treated with JHU083 (0.3 mg/kg) daily starting on day 14 after tumor inoculation

Neuropsychopharmacology 42:271283

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Some studies showed a positive correlation between increased intestinal permeability (measured as the lactulose/mannitol ratio), ethanolaemia, endoxaemia, and the degree of liver damage [47]

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Nonetheless, the existence of a biological interplay among OS, aging, and ALS has been presumed for more than two decades [325] and it is now becoming more evident [326]