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[DOI] [PMC free article] [PubMed] [Google Scholar] 205.Lawson K
Nevertheless, these discussions in no way include the multifactorial nature of the disease processes encompassing IBD, and intentionally have not included potential implications of genetic predispositions, spontaneous immune deregulations, proteases, and microbiota, which are discussed in great detail in other great review articles

It is estimated that 1.5 million bone grafting procedures are performed annually in the USA and this figure is rapidly increasing due to population ageing [2, 7, 913]

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