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Serious adverse effects appear rare but remain possible until more comprehensive long-term studies are completed

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86 In this model, CLP induced PMN infiltration in the peritoneal cavity, the site of infection, as well as in the lung, ultimately resulting in lung injury and death, with a concomitant decrease in endogenous GSH

Joint aspiration for laboratory analysis may ultimately be required, as it can identify urate crystals, and Gram stain or culture can confirm/exclude the presence of infection

The relationship between AOD9604 activity and adrenergic pathways and energy metabolism also remains an important area of scientific interest

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