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In AD models, it decreases astrocyte activation through JAK2/STAT3 pathway inhibition, requiring careful dose control to preserve neuronal viability (275)

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Dang VC, Napier IA, Christie MJ: Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neurons

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[DOI] [PubMed] [Google Scholar] 125.Marracci G.H., Jones R.E., McKeon G.P., Bourdette D.N