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confirmed that nicotine exposure, a key product of cigarettes, triggered oxidative stress in pancreatic stellate cells via induction of the mitochondrial dynamics towards fission as shown by upregulation of Drp1 and smaller, fragmented-shaped mitochondria

Eur J Pharmacol 951:175748

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R.McfarlaneJ

SAH is a potent competitive inhibitor of methylation reactions so that prompt removal of Hcy and adenosine is required to prevent SAH accumulation

Fujitani K, Ajani JA, Crane CH, Feig BW, Pisters PW, Janjan N, Walsh GL, Swisher SG, Vaporciyan AA, Rice D, Welch A, Baker J, Faust J, Mansfield PF