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However, translating these findings into clinically viable therapeutics remains a major challenge

Knockout mice studies suggest a pivotal role of apical transporter SLC26A6 in back-secretion of oxalate that limits its net intestinal absorption, as gene deletion of SLC26A6 results in significant hyperoxaluria [46, 47]

NRF1 regulates gene expression related to mitochondrial respiration, heme formation, and the import and assembly of mitochondrial proteins

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