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Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

Studies have shown improved nerve conduction and symptom reduction with this active form

This may represent a normal part of follicle cycling acceleration rather than a true adverse effect

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Treadmill exercise rescues mitochondrial function and motor behavior in the CAG140 knock-in mouse model of Huntingtons disease