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These transgenic mice showed significantly reduced plasma testosterone levels (18% of normal)[124] and the IGF-I deficiency was correlated with an ultrastructural analysis of mutant Leydig cells revealing a significant developmental delay, with fewer and smaller Leydig cells than normal

Quarterly ALL PPS meetings to discuss and clarify currently relevant DSRIP program protocols and progress benchmarks Annual Learning Collaboratives as required by the STCs where PPS can showcase collaborative, transformational and innovative DSRIP activities

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Common medications include corticosteroids, methotrexate, antiTNF antibodies, and intravenous immunoglobulin