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In the current MASLD era, methotrexate-induced hepatotoxicity must be understood in the context of host metabolic dysfunction, obesity, diabetes, and alcohol use that amplify oxidative and inflammatory liver injury

Interestingly, l-serine synthesis as well as glucose oxidation were altered in DCM iPSC-CMs compared with cells that were genetically corrected, and serine supplementation also drove improvements in iPSC-CM function

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[DOI] [PubMed] [Google Scholar] 102.Song E., Su C., Fu J., Xia X., Yang S., Xiao C., Lu B., Chen H., Sun Z., Wu S., et al

also reported that reduced IGF-1 in serum is associated with cognitive deficits in subjects with AD [84]