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Therefore, the cellular uptake of glucose is promoted, and the synthesis of glycogen increases thus lowering the blood glucose concentration ( Figure 1 2.2 Ras-mitogen-activated protein kinase pathway/growth signalling pathway The MAPK families include c-Jun N-terminal kinase (JNK), p38 and extracellular-signal-regulated kinase (ERK) in mammals ( 2.3 Pathophysiology of insulin resistance The metabolic action of insulin is to maintain glucose homeostasis by suppressing glucose production in the liver and by promoting glucose uptake in the skeletal muscle and adipose tissue ( Various factors such as genetics, stress, lack of exercise, and aging contribute to insulin resistance ( 3 Mitochondria and metabolism of substrates Mitochondria are double-membraned organelles that surround a space known as a matrix