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Ghrelin and Regulate Appetite: The arcuate nucleus (ARC) of the hypothalamus and brainstem is an important area involved in the regulation of appetite, body weight and energy balance [15]

L., Daz-Mesa, E., Abreu-Gonzalez, P., Fernandez-Lopez, L

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Abbreviations AE: Adverse events AUC: Area under the plasma concentration time curve BID: Twice daily CI: Confidence interval CL: Clearance C max : Maximum observed plasma concentration COPD: Chronic obstructive pulmonary disease CS: Closed system CV%: Coefficient of variation DPI: Dry powder inhaler F: Fraction bioavailable FEV 1 : Forced expiratory volume in 1 s FVC: Forced vital capacity GLY: Glycopyrronium bromide GOLD: Global Initiative for Chronic Obstructive Lung Disease ICS: Inhaled corticosteroid IV: Intravenous LAMA: Long-acting muscarinic antagonist LS: Least squares PK: Pharmacokinetics pMDI: Pressurized metered dose inhaler SAE: Serious adverse event SD: Standard deviation t : Elimination half-life t max : Time to reach maximum plasma concentration V ss : Volume of distribution at steady state V z : Volume of distribution References Decramer M, Janssens W, Miravitlles M