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Funding This work was supported by the National Natural Science Foundation of China (Grants 31530016, 32090031, and 31761133012), the National Basic Research Program of China (Grant 2017YFA0503900), and the Shenzhen Science and Technology Innovation Commission (Grants JCYJ20180507182213033 and JCYJ20170412113009742)

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Studies show green tea polyphenols reduce cell damage and DNA mutations caused by toxins

5 Riboflavin in gene therapy and molecular targeting of neurological disorders With the advent of high-throughput sequencing and broader genetic testing, an increasing number of inherited neurometabolic disorders linked to riboflavin metabolism have been identified

Furthermore, inflammation, aging, genetic factors, and environmental pollution, are all elements promoting ROS generation and impairing antioxidant defense mechanisms and thereby representing risk factors leading to oxidative stress