fsp1 is a glutathione independent ferroptosis suppressor Protein 1 Inhibition Promotes Tumor Ferroptosis and Anti-tumor Immune Responses in Liver Cancer Regulatory pathways independent of GPX4
Description
exposed HepG2 cells to 520 M TSN for up to 24 h and showed a 15% loss of cell viability that correlated with partial GSH depletion, a three-fold increase in LPO, and reduced GPx4 expression
However, certain medications can affect its efficacy
For example, the MEK inhibitor trametinib combined with 5-FU has been shown to synergistically suppress the MAPK pathway and enhance the response to neoadjuvant chemoradiotherapy [156]
Its a downward spiral with no end in sight
8, Interactions
Understanding how these two compounds interact is the first step toward building a more effective wellness routine
