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Macrophage phenotypes in atherosclerosis

Xantine oxidase (XO), proven to be present in both the intestinal mucosa and liver, converts 6-MP into 6-thioxanthine (6-TX) and subsequently into thiouric acid (TU)

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As a result, misfolded and polyubiquitinated proteins accumulate within the ER, activating the UPR and promoting apoptosis

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Chen L, Shi X, Liu H, Mao X, Gui L-N, Wang H, Cheng Y (2021) Oxidative stress marker aberrations in children with autism spectrum disorder: a systematic review and meta-analysis of 87 studies (N = 9109)