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Peer review Peer review information Nature thanks Ignas Snellen and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Document daily dose, injection site, and any adverse reactions to maintain consistency and identify patterns

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The absence of mucin, a highly glycosylated polymeric protein in the mucous layer, makes an animal vulnerable to intestinal inflammation, which leads to the development of spontaneous colitis and confers a predisposition to the development of colorectal cancers (Fig