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Additionally, the gene has a typical promoter that contains the sequences TATAAAT and CAAT 29, and is 81 base pairs upstream of the cap site [47]

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It is characterized by symmetric hyperpigmentation of the vulvar region, particularly in the perianal skin, posterior introitus, and the tips of the labia minora [7, 9]

Two significant limitations noted when performing this narrative review that could be addressed in future medical research are drug-drug and drug-disease interactions, as seen in a case report reviewing a patient undergoing first-line chemotherapy for metastatic colon cancer, who subsequently sustained an ischaemic priapism post oxaliplatin infusion [56]

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