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Holy et al., 2009)

Akaike, T

In addition, as mitochondrial diseases particularly affect tissues and cells that are highly dependent on mitochondrial energy production (such as neuronal, muscle and cardiac cells) (Pfeffer et al., 2013), the use of brain organoids to study the role of mitochondria in neurodevelopmental disorders is a revolutionary strategy

In recent years, in addition to its pyruvate kinase function, PKM2 has sparked considerable interest for its noncanonical function, which regulates gene expression as a transcription factor coactivator of Hif-1, -catenin, and p53 30,31,32 or phosphorylates proteins as a protein kinase 33,34,35,36

doi: 10.1093/oxfordjournals.bmb.a072641

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