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Springer, Berlin, Heidelberg, pp 139156

The traditional research paradigm has primarily focused on analyzing the interaction between antibiotics and direct targets within bacterial cells ( Bacterial survival and proliferation heavily rely on their metabolic activities, which not only support fundamental physiological processes but also influence the cells capacity to adapt to its external environment ( -lactam antibiotics, distinguished by their unique -lactam ring structure, serve as widely utilized antimicrobial agents

Studies have shown that cells with reduced NAD+ levels exhibit significantly impaired DNA repair capacity, with 40-60% reductions in repair efficiency when NAD+ levels decrease by 50%