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In 1998, the recommended dietary allowance for all women of child bearing age who are capable of becoming pregnant was increased to 400 mcg of folic acid daily

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J Cancer Res Clin Oncol (2008) 134(5):5519

including adult patients with either T1D or T2D treating with mecasermin rinfabate (12 mg/kg/day for 14 days) showed lowered exogenous insulin requirements while improving glycaemic control