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Next, we will discuss each of these strategies in detail, exploring their specific effects, mechanisms, and potential clinical applications

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GH secretagogues are generally administered subcutaneously

A study showed that the 6-hydroxydopamine (6-OHDA), a neurotoxin that is commonly used to develop animal models of Parkinson's disease, reduces DBH and induces mitochondrial ROS production, which subsequently leads to the lysosomal degradation of cupper-trafficking protein such as ATP7A, which is essential for redox balance in mitochondria (Kondo, 2021, Bhattacharjee, 2016)

However, DNA hypomethylation is not universal in PD contexts, since several genes, including PD-risk genes, are reported to be differentially methylated (and not only hypo-methylated as expected) [243]