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This apparent loss of reactive species production ex vivo is further supported by our observation that the antioxidant BHA, used as a positive control, did not enhance antibiotic killing in these conditions (Extended Data Fig

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In the context of the Cagrilintide pathway, this suggests that the LEPR portion of body-weight regulation is more likely to function within the expected range, helping support more typical communication between adipose tissue and the brain regarding hunger and energy stores

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