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In conclusion, mROS and mROS scavenging structures which simultaneously target the tumors, may bring about anti-cancer responses thus overcoming malignant transformation and further cancer growth

If these safeguards fail, the cells may continue replicating and potentially develop into a lesion [195]

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Direct and indirect enhancement of GABAergic neurotransmission by ammonia: implications for the pathogenesis of hyperammonemic syndromes

For example, in tumors with active growth factor receptor signaling (e.g., HER2 amplification), tamoxifen may lose its estrogen antagonist activity and acquire more agonist-like activity, resulting in tumor growth stimulation [34]