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Iannielli et al., 2018)

Histopathological improvements have been observed after treatment with silymarin and silibinin, including restored liver architecture and reduced necrosis and cancer-related alterations

Due to the stable tumor formation and relatively consistent growth rate of HCCLM3 cells in subcutaneous transplantation models, HCCLM3 cells were selected for animal modeling

However, this was not in agreement with the decrease in blood pressure seen in this model

Can J Physiol Pharmacol 2006