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90,91 Additionally, the activity of epigenetics-modifying enzymes and their cofactors, such as TET and -ketoglutarate (-KG) from the tricarboxylic acid cycle (TCA), can be influenced by abnormal metabolite levels in patients with metabolic diseases, further disrupting epigenetic regulation and exacerbating disease progression

Clin Exp Pharmacol Physiol 48(8):10591069

Auta, J., Zhang, H., Pandey, S

TXN and TXNRD are primarily expressed in pulmonary epithelial cells, alveolar macrophages, and bronchial chondrocytes in neonates, and they function as antioxidants (66)

Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 20002014

Measurements of CB1 radioligand binding have provided mixed results, with some studies indicating that receptor numbers are diminished by this chronic drug exposure, while others report no change (Abood et al., 1993