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The hypoxic stress inside cells activates a family of transcriptional factors called Hypoxia Inducible Factors (HIF-1, HIF-2, HIF-3) [3,22]

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For example, Coca-Cola-owned Smartwater is a distilled bottled water brand claiming a balanced pH of 7.0, but their competitor Waikea states Smartwater has a pH of 6.5

This suggests a general regulatory effect on protein breakdown in skin, helping to prevent both buildup of damaged proteins and excessive proteolysis [10,11]

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