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Antioxidants 13(3):303 Deshmukh P et al (2017) The Keap1Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases

It also affects the same person differently on different occasions

The two receptor components move to the cell surface and combine into a functional unit

112 More recently, it was suggested that methotrexate causes ferroptosis through activation of autophagy, leading to increased degradation of ferritin and liberation of ferrous iron (ferritinophagy), which promotes LPO and liver injury

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