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Clinical Symptoms Initial symptoms: capillary congestion and swelling, especially of the extremities (Raynaud's phenomenon)

Healthcare providers must weigh the benefits against the risks for each patient. As we keep exploring the complex link between vitamin B12 and chemotherapy , its clear that one-size-fits-all advice is not right for nutritional supplements during cancer treatment

Obeid R et al

Without adequate intake of B12, vegans can easily develop deficiency over time, leading to symptoms such as fatigue, weakness, constipation, loss of appetite, weight loss, and nerve problems therefore the researchers recommend that vegans and vegetarians should add vitamin B12 to their diet by eating fermented foods, particular types of mushroom that contain the vitamin and B12-enriched vegetables

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Considering millions of people are injecting B12, you get the idea how uncommon allergic reactions are