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Intracellularly, ROS are principally generated by mitochondrial respiration and redox enzymes, such as uncoupled nitric oxide synthase, cytochrome P-450 isoforms, and NADPH oxidase subtypes (NOXs), in the form of superoxide (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 150.Murugan M., Boison D

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Author Contributions: Conceptualization: Yang L

The CD36 KO model is particularly relevant given the established relationship between PFO and CD36 in humans [33] and the observed impaired fatty acid oxidation in mice lacking CD36 [28, 35, 47]
