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On the other hand, the oxidative stress was higher in transgenic mice overexpressing CYP2E1 [151], or in mice infected with an adenovirus to overexpress Cyp2e1 gene and in HepG2 cells transduced with an adenovirus encoding the human CYP2E1 gene [152]

Detoxification Glutathione supports liver function by aiding in the detoxification of harmful substances, including heavy metals and toxins

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Another important function of glutathione is mediated by its conjugation to several substrates

KA is reported in the literature with contradicting inhibition mechanisms, while HQ is described as both a tyrosinase inhibitor and a substrate

The need for nucleotide substrates increases substantially during inflammation, injury and wound healing, and consistently, disease severity correlated with loss of hypoxanthine in the epithelium in a chemically induced murine model of colitis 123